Functional status is the hallmark by which geriatric care is measured.
Medication use is a known risk factor for functional status decline, but a recent review of studies on the topic revealed that some drug classes are associated with greater functional decline than others.
The literature review included 19 studies that looked at the relationship between medication use and type and functional decline among older adults. In general, as the number of prescriptions increased, so did functional decline.
Specifically, three of four studies found a negative association between functional decline and the use of benzodiazepines. There was also a relationship found between worse functional status and increasing exposure to anticholinergic medications. Other studies produced mixed results for other drug classes, such as antidepressants and antihypertensives.
See results in Perone, E.P. et al. (2011). Medication use and functional status decline in older adults: A narrative review. The American Journal of Geriatric Pharmacotherapy, 9(6), 378-391.