• CoronaCoronavirus (COVID-19) Resources

    In an effort to support our members with the most updated information on COVID-19 we developed this resource page to easily access current CDC information and other resources to assist you professionally and personally.

    We will continue to update this page with more information as it becomes available and welcome your input as we navigate through this situation. As health care professionals it is our job to educate our patients and families on prevention and the what to do if someone is symptomatic.

    View resources

     

  • Clinical Care OptionsNew for GAPNA members: Clinical Care Options

    GAPNA has partnered with a Clinical Care Options to offer an ongoing series of free CNE programs available to GAPNA members. "Vaccinations and Healthy Aging: Protecting Your Older Patients From Shingles" is the latest program offered.

    In this live webinar, expert faculty expert faculty discuss how important it is to prevent shingles in older patients.

    Find out about it!

  • GAPNA 2020 National President Deborah Dunn, EdD, MSN, GNP-BC, ACNS-BC, GS-C interviews Dr. Ron Billano Ordona, DNP, FNP-BC about providing home-based primary care during COVID 19.

    "Facing Forward: Providing Home-based Primary Care during COVID 19"


    View the Video

Lonhala Magnair

Early-Stage Modeling

Animal Model Mimics Earliest Stages of Alzheimer’s in Humans

A new research model using adult rhesus monkeys mimics some of the earliest abnormalities of Alzheimer’s disease and could pave the way for a better understanding of how the disease begins in humans, according to research published in Proceedings of the National Academy of Sciences.

Developed by scientists at the California National Primate Research Center of the University of California, Davis, this preliminary model provides a potential alternative to those that have not translated well to human clinical studies. Most mouse models are based on single-gene mutations associated with early-onset Alzheimer’s disease. In this study, researchers sought to create a model of the more common sporadic Alzheimer’s and to study how protein fragments affect the prefrontal cortex, which functions similarly in humans.

Researchers focused on impairment to synapses through which electrical or chemical signals pass, allowing neurons to communicate. Keeping synapses in good working order could be the key to preventing neuronal death, inflammation, and other Alzheimer’s-related brain damage that lead to age-related cognitive decline and dementia.

The study showed that rhesus monkeys may be a good model for studying the early synaptic dysfunction of Alzheimer’s disease, the authors concluded. Further research could determine if the model is useful for studying tau, another harmful protein in Alzheimer’s, and for exploring the mechanism underlying oligomer accumulation in Alzheimer’s.

To learn more, see Beckman, D. et al. (2019). Oligomeric Aβ in the monkey brain impacts synaptic integrity and induces accelerated cortical aging. Proceedings of the National Academy of Sciences, 116(52), 26239-26246. https://doi.org/10.1073/pnas.1902301116