• 2020 GAPNA Pharmacology Conference: Contemporary Pharmacology and Prescribing in Older AdultsJoin us at the 2020 GAPNA Pharmacology Conference:
    Contemporary Pharmacology and Prescribing in Older Adults

    April 14-18, 2020, Honolulu, HI.

    Earn up to 18 CNE hours.

     

    Find out more about it and REGISTER today!

  • W A N T E D   G A P N A   L E A D E R S!
    Call for Nominations!

    Have you ever considered stepping forward, accepting the challenge and volunteering for a position on the 2020-21 National Board of Directors? Register online NOW by March 22, 2020!

    Step Up - NOW is the Time! Register Here>

  • AwardNew for GAPNA members: MCM Education

    GAPNA has partnered with a MCM Education to offer an ongoing series of CNE programs available to GAPNA members. "Diagnosing and Managing Parkinson’s Disease in Older Adults," is the latest program offered.

    Parkinson’s disease (PD) is characterized by both motor and nonmotor symptoms. It is diagnosed based on the presence of two of four motor symptoms including rest tremor, bradykinesia, rigidity, and gait imbalance...

    Find out about it!

  • ConventionCALL FOR: Podium and Poster Abstracts

    For the 38th GAPNA Annual Conference
    at the Hyatt Regency
    New Orleans, LA, September 24-26, 2020

    GAPNA members are invited to submit an abstract about their innovative work, that should enrich the APRN's knowledge and/or enhance the care of an older adult. Deadline March 15, 2020.

    Find out more info and deadline dates

  • FREE CE for GAPNA MembersFREE continuing education credit is available for the following session:

    "Update in Chronic Kidney Disease Management and Prescribing"

    (session captured at the GAPNA 2018 Annual Conference)


    For January/February 2020 - Get Your Free CNE Now!

Predicting Amyloid Deposits

Blood Test May Predict Amyloid Deposits in Brain, Potentially Indicating Alzheimer’s Disease

A number of research projects are underway to develop a sensitive blood test that could help screen people for Alzheimer’s disease in a less-invasive and costly way than current imaging and biomarker tests.

Researchers recently reported an advance for their method of detecting amyloid protein in blood (Schindler et al., 2019) and are validating the method by showing an association between blood levels of amyloid and results from conventional biomarker tests for Alzheimer’s.

Using a technique called immunoprecipitation mass spectrometry, researchers developed a precise method for quantifying how much beta-amyloid 42 and beta-amyloid 40 are in a sample of blood. Previous studies have suggested the ratio of these two forms of beta-amyloid may correspond with amyloid in the brain (watch viedo below).

Next, the researchers analyzed the blood of 158 adults (average age, 66), most without dementia symptoms, using their sensitive method, and evaluated them with positron emission tomography (PET) imaging and cerebrospinal fluid tests. Results indicated the ratio of beta-amyloid 42 and beta-amyloid 40 in blood was associated with the detection of amyloid by PET scans and cerebrospinal fluid tests.

Researchers then added other factors to their statistical model to help predict which people would have amyloid deposits with PET imaging. By adding age and APOE genetic status to the blood test results, the model was significantly better at predicting which people would have amyloid detected by PET scans.

Studies are already in progress to further evaluate this method with people who have symptoms of Alzheimer’s disease. Ideally, future studies would use tissue samples from postmortem brains rather than the less-sensitive images of plaques from PET scans to assess the relationship between the ratio of beta-amyloid 42 and beta-amyloid 40 and amyloid plaques in the brain. After more development and validation, this blood test method may help researchers to quickly screen people for eligibility in Alzheimer’s studies.

Reference

  • Schindler, S.E., Bollinger, J.G., Ovod, V., Mawuenyega, K.G., Gordon, B.A., Holtzman, D.M., … Bateman, R.J. (2019). High-precision plasma β-amyloid 42/40 predicts current and future brain amyloidosis. Neurology, 93(17), e1647-e1659. 2019. https://doi.org/10.1212/WNL.0000000000008081

Join your friends in Honolulu, Hawaii at the 2020 GAPNA Contemporary Pharmacology and Prescribing in Older Adults Conference on April 14-18, 2020.

Learn more and register today!