• 2019 GAPNA Pharmacology Conference: Contemporary Pharmacology and Prescribing in Older AdultsJoin us at the 2019 GAPNA Pharmacology Conference:
    Contemporary Pharmacology and Prescribing in Older Adults

    March 28-30, 2019, Chicago Hilton, Chicago, IL.

    Earn up to 11.5 CNE hours.

     

    Find out more about it and REGISTER today!

  • AwardCall for Excellence Award Nominations

    The awards are: Emerging Chapter Award, Established Chapter Excellence Award, Special Interest Group Excellence Award, Excellence in Clinical Practice Award, Excellence in Community Service Award, Excellence in Education Award, Excellence in Leadership Award, and Excellence in Research Award.

    The nominations are tallied in July and the winners are announced every year during the Awards Celebration at the GAPNA Annual Conference.

    Now is the time to nominate a colleague or yourself - DEADLINE is June 1, 2018.

    Get started... nominate today!

  • W A N T E D   G A P N A   L E A D E R S!
    Call for Nominations!

    Have you ever considered stepping forward, accepting the challenge and volunteering for a position on the 2019 National Board of Directors? Register online NOW by April 1, 2019!

    Step Up - NOW is the Time! Register Here>

  • FREE continuing education credit is available for the following session:

    "Keynote Address - Health Policy: APRNs Working to the Full Extent of the Law"

    (session captured at the GAPNA 2018 Annual Conference)


    For March/April 2019 - Get Your Free CNE Now!

  • Poster Presentation

       

    This 22-module curriculum provides a basic knowledge base for Nurse Practitioners who looking to advance their expertise in caring for patients with dementia.
     

    FREE to GAPNA members until September 1, 2019

  • GAPNA Exchange

       

    GAPNA Exchange is a private, secure community for members to share ideas, ask questions, lend expertise, and network with peers.

    It features both an Open Forum discussion area along with smaller, segmented communities.

    Interact with GAPNA members wherever and whenever!

    Go to GAPNA Exchange

Combating Cognitive Decline

Could Boosting Lymphatic Function Combat Age-Related Cognitive Decline?

Scientists only recently discovered lymphatic vessels in the brain that remove cellular debris and other waste. Now, new research published in Nature on July 25, 2018, suggests these vessels could play a role in age-related cognitive decline and Alzheimer’s disease.

Researchers from the University of Virginia, Charlottesville, studied the performance of lymphatic vessels in the brains of mice and the drainage of cerebral spinal fluid (CSF) from blood vessels into the lymph nodes – also known as the brain’s waste-removal system.

Using methods that impaired the function of the lymphatic vessels in younger mice resulted in decreased drainage of large molecules from CSF into lymph nodes, reduced flow of CSF in certain areas of the brain involved in learning and memory, and reduced spatial learning and memory abilities.

Researchers compared the function of lymphatic vessels in younger and older mice. They found that in older mice, lymphatic vessels were narrower, and large molecules did not drain out of the CSF into the lymph nodes as well. Using a method to boost lymphatic function in older mice resulted in improved cognitive function.

Researchers also found that impairing brain lymphatic vessels in mouse models of Alzheimer’s disease led to higher levels of amyloid-beta deposits in the tissue covering the brain as the mice aged. Abnormal buildup of the protein amyloid-beta is a factor in Alzheimer’s disease. The researchers’ findings in the mouse models were mirrored in postmortem analysis on the brains of nine people who had Alzheimer’s disease.

According to the researchers, determining whether altering lymphatic vessels in people would have similar benefit to what was seen in the mouse models requires further study, but these initial findings could point to a new possible target for preventing or delaying age-related cognitive decline and Alzheimer’s disease.

For details, see Da Mesquita et al. (2018). Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease. Nature, 560(7717), 185-191.

Join your friends at the 2019 Contemporary Pharmacology and Prescribing in Older Adults Conference, March 28-30, 2019, in Chicago, IL.

Register today!